My essay aims to demonstrate that Neoliberalism exercises its art of government on forms of life turning their potentiality into adaptability. According with one of most influential reference thinker of Neoliberalism, Friedrich von Hayek, the spontaneous order of the market requests the constant adaptation of individuals to circumstances of which no one can be aware and can master. However, such adaptability – that could come from a certain negative philosophical anthropology – is the reverse side of the same potentiality theorized by authors of Italian Thought like Agamben, Esposito and exponents of Post-Operaism. The paper aims to focus the condition for which such conversion of potentiality into adaptability is prevented.