The critical note aims to analyse the influence, the points of contact between Gilles Deleuze and what is now called Italian Thought. The discussion is developed starting from some precise issues taken from the book: Effetto Italian Thought, edited by Enrica Lisciani-Petrini e Giuseppina Strummiello, pub- lished in 2017 by Quodlibet. The main questions addressed are: 1. In what sense can the Italian Thought be defined as an actual thought? Collecting many ideas from the Enrica Lisciani-Petrini’s postface, we will try to argue that an actual thought must be configured as a philosophy of dispositives. The Deleuzian work examined in this regard will be the text of a conference that Deleuze dedicates to Michel Foucault: What is a dispositive? 2. All the heterogeneity of Italian Thought will emerge from the comparison between Roberto Esposito and Toni Negri (published in the first part of the book) about what should be understood by affirmative biopolitics.